WELCOME

This year’s edition of the annual meeting Sociedade Portuguesa de Imunologia (SPI) will be at IMM (Instituto de Medicina Molecular João Lobo Antunes), in Lisbon, from the 27th to 29th of June, 2018.

This meeting will focus on Metabolism, Cancer, Vaccines, Infection, Mucosal Immunology, Immune Regulation and Lymphocyte activation. We are privileged to host a fantastic panel of speakers (see details below).

We welcome your participation.
See you there,

The organizing committee,

Ana Espada Sousa
Bruno Silva-Santos
Luís Graça
Marc Veldhoen
Alexandre Carmo
Jocelyne Demengeot
Natacha Gonçalves Sousa

 

SPEAKERS

Metabolism & Cancer Session

Ana I. Domingos
University of Oxford, UK, Howard Hughes Medical Institute IRS, Maryland, US, Gulbenkian Science Institute, Portugal

Title: Sympathetic Neuroimmunity in Obesity

The laboratory of Dr Domingos focuses on neuroimmune mechanisms underlying obesity. Using optogenetics and multiphoton microscopy, among other tools, the laboratory of Dr Domingos has recently discovered a direct connection between adipocytes and the sympathetic nervous system (SNS). Moreover, they showed that this SNS neuro-adipose junction mediates fat mass reduction. Thus, direct and targeted pharmacologic activation of sympathetic inputs to adipose tissues could represent a novel strategy for the induction of fat loss and a new anti-obesity therapy that would circumvent the challenges of drug delivery to the brain. Howard Hughes Medical Institute, the Welcome Trust, the Human Frontiers Science Program, the European Molecular Biology Organization, and the Gulbenkian Foundation fund the laboratory of Dr Domingos. She has undergraduate training in mathematics, doctoral training in neurobiology mentored by Prof. Dr Leslie Vosshall and postdoctoral training in metabolism mentored by Prof. Dr Jeffrey Friedman, both at the Rockefeller University.

Steffen Jung
Weizmann Institute of Science, Israel

Title: HSC-Derived Macrophages in Gut and Brain

Steffen Jung was born in Homburg/ Saar, Germany. After undergraduate studies at the University of Bonn, he moved to the Institute of Genetics in Cologne. In the Department of Immunology headed by Klaus Rajewsky, he performed his PhD under the guidance of Andreas Radbruch. Specifically, he used the newly developed gene targeting approach to define cis-acting control elements driving non-coding “sterile” transcripts in immunoglobulin class switch recombination. After completion of his PhD in 1993, he moved for post-doctoral training to Israel and joined the laboratory of Yinon Ben-Neriah at the Lautenberg Center (Hebrew University, Jerusalem) studying transcription factors and kinases in T cell signalling. In 1997, Steffen Jung went to New York for a second post-doc in the laboratory of Prof. Dan Littman at the Skirball Institute for Molecular Pathogenesis, NYU Medical Center. His studies there focused on the then newly discovered chemokine receptor CX3CR1 and its membrane-tethered ligand CX3CL1/ fractalkine. He generated CX3CR1gfp mice that became as reporter strain instrumental to define murine monocyte subsets and brain microglia. Furthermore, he developed in collaboration with Richard Lang at the Skirball a novel diphtheria toxin-based transgenic mouse model that allowed the study of dendritic cells (DC) in their in vivo context by conditional cell ablation (CD11c-DTR mice). In 2002, Steffen Jung returned to Israel and joined the Department of Immunology at the Weizmann Institute, where he received tenure in 2009 and was promoted to Full Professor in 2015. He currently acts as Head of the Department of Immunology.
Present work of the Jung lab aims at elucidating in vivo aspects of mononuclear phagocyte biology, including the definition of developmental pathways and differential functions of monocytes, DC and macrophages. Specifically, the team uses conditional mutagenesis, in vivo cell imaging, cell ablation and transfer strategies, as well as gene expression and epigenome profiling to investigate the biology of these cells in physiological context in health and disease. Focus is given to the study of monocyte-derived intestinal macrophages and yolk sac-derived microglia in physiology and pathophysiology.

Lucie Peduto
Institut Pasteur, France

Title: The Stromal Niche in Tissue Repair, Inflammation and Cancer

Lucie Peduto obtained her PhD from the University of Lausanne (Switzerland) in tumor biology. She did a postdoctoral fellowship at the Sloan-Kettering Institute, in New York, on the role of ADAMs proteases in the tumor microenvironment. She is now Associate Professor in the Department of Immunology, at the Institut Pasteur (France), directing a laboratory focusing on the role of stromal cells in inflammation and cancer. Her lab is more specifically interested in the stromal crosstalk with immune cells, endothelial cells and tissue stem cells, and exploring how perturbation of this fundamental crosstalk impact on disease pathogenesis. Lucie Peduto was awarded an ERC Consolidator Grant to pursue her research on the role of the stromal microenvironment in inflammatory/fibrotic diseases and cancer, aiming at identifying new (co)-therapeutic strategies.

Burkhard Becher
University of Zurich, Switzerland

Title: The T Cell-Myeloid Connection in Tissue-Inflammation

Burkhard Becher studied Biology at the University of Cologne in Germany and specialized in Molecular Genetics and Biochemistry. In 1995, for his graduate studies he went to the Montreal Neurological Inst. at McGill University in Canada to train in Neuroimmunology with Jack Antel. His work focused on the role of microglia cells as brain-resident myeloid cells capable of instructing self-reactive T cells in the context of autoimmune neuro-inflammation. In 1999 he joined the lab of Randy Noelle at the Dartmouth Medical School to extend his work to in vivo models and transgenic mice. He developed tools to specifically manipulate microglial cells in vivo during inflammation. Burkhard’s focus is the function of cytokines and how these molecules permit cell-cell communication between immune cells. In 2003, he was recruited as Assistant Professor to the Neurology Department at the University Hospital of Zurich. There he continued to define the cytokine networks in inflammation. In 2008, he became full professor and chairman at the Institute of Experimental Immunology at the University of Zurich and heads the Unit for Inflammation Research.

VACCINES & INFECTION SESSION

Andre Ballesteros-Tato
Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Alabama, USA.

Title: Regulation of the Germinal Center response to Influenza virus by IL-2

Andre completed his Ph.D. in Molecular Biology at the Autonoma University of Madrid in Spain in July 2007. In his Ph.D. thesis work, he studied the role of the cell cycle inhibitor p21 and the apoptosis-inducing Fas receptor in controlling immunological tolerance in different murine and human autoimmune diseases. Beginning in March of 2008, Andre joined the laboratory of Dr. Troy Randall at Trudeau Institute as a postdoctoral fellow, and then later moved with Dr. Randall’s lab to the University of Rochester. As a postdoc, he studied how dendritic cell (DC) subsets responded to influenza infection and how they controlled CD8+ T cell priming and promoted memory T cell differentiation. These previous studies have stimulated his interest in how cells of the innate immune system, particularly DCs, monocytes and their progeny, control both early inflammation and ultimately T and B cell responses to pathogens. After joining the University of Alabama as an assistant professor in June 2015, Andre’s laboratory is studying the cellular interactions, the environmental cues and the molecular mechanisms that control the differential capacity of distinct populations of DCs to regulate T and B cells responses in different models of infection and autoimmune diseases.

Ziv Shulman
Weizmann Institute of Science, Israel

Title: Germinal Centers: Arrivals, Departures and the T Cell Border Control

Ziv Shulman is a principal investigator at the department of immunology in the Weizmann Institute of Science. He received his MSc and PhD degrees from the Weizmann Institute, studying immune cell migration. He did his postdoctoral fellowship at the Rockefeller University in New York City where he studied the process of antibody affinity maturation.
Ziv Shulman is a Human Frontiers of Science fellow as well as Azrieli foundation fellow.

Matteo Iannacone
San Raffaele Scientific Institute, Milan, Italy

Title: Spatiotemporal Dynamics of Naive CD8+ T Cells Undergoing Intrahepatic Priming

Matteo Iannacone obtained a M.D. degree from the University of Milan, Italy, followed by a residency in Internal Medicine and a Ph.D. in Immunology from Vita-Salute San Raffaele University in Milan, Italy. He trained as a postdoctoral fellow at The Scripps Research Institute, La Jolla, CA and at Harvard Medical School, Boston, MA. Since 2010, he directs the Dynamics of Immune Responses Laboratory at the San Raffaele Scientific Institute in Milan, Italy. By combining cutting-edge in vivo imaging techniques and advanced animal models, Matteo has made fundamental contributions to our understanding of the immune response and viral-induced immunopathology. His work has been published in the most important scientific journals (including Nature, Science, Cell, Immunity, Nature Medicine) and he holds 6 international patents. He has received numerous awards for his work, including the Armenise-Harvard Foundation Career Development Award, an ERC Starting Grant, the Young Investigator Award from the European Association for the Study of the Liver, the EMBO Young Investigator Award, the Chiara D’Onofrio Award and an ERC Consolidator Grant.

MUCOSAL IMMUNOLOGY & IMMUNE REGULATION SESSION

Denise Morais da Fonseca
University of São Paulo, Brazil

Title: Immunological Scarring. Understanding Chronic Effects of Acute Infections

Denise Morais da Fonseca is an Assistant Professor at the Institute of Biomedical Sciences – University of São Paulo – Brazil. She obtained her Ph.D. in 2010 from the University of São Paulo on the regulation of the immune response during airway inflammation. Following a postdoctoral period at the University of São Paulo, working on immune regulation during intestinal parasitic infections, she joined the Laboratory of Parasitic Diseases – National Institutes of Allergy and Infectious Diseases, USA in 2012 as post-doctoral fellow. Since then, her work over the past years aims at understanding how acute infections at mucosal barriers, such as the gut and lungs, have long-term impact on tissue function and homeostasis. Barrier tissues are sites of constitutive colonization by commensals and exposition to environmental antigens. Therefore, the mucosal-associated immune system is endowed with specialized mechanisms of immunity and regulation, allowing for the tolerance of constant exposure to innocuous antigens while maintaining the capacity to rapidly respond to encounters with pathogens. Failure to restore initial homeostasis post-infection and the long-term consequences of encounters with pathogens have been the focus of our current studies. The scientific goal of the Laboratory of Mucosal Immunology is to understand the mechanisms underlying the development of systemic immune and metabolic pathologies following acute infections. More particularly, their research plan aims to 1) identify the mechanisms sustaining the infection-induced scarring/remodeling of the immune system, 2) define how infection-induced remodeling of the mesentery drives the development of host metabolic dysfunction, and 3) describe the main pathways mediating the regulation of immune homeostasis in the adipose tissue and susceptibility to metabolic disease.

William Agace
Lund University Sweden and Technical University of Denmark, Denmark

Title: Dendritic Cell Subsets in the Regulation of Intestinal Immune Responses

William Agace has been working in the field of mucosal immunology for over 25 years. Major contributions to the field include the identification of the CCR9/CCL25 axis in mediating T cell recruitment to the small intestine, that ‘gut tropic’ T cells are preferentially generated in intestinal inductive sites, the identification of intestinal CD103+ dendritic cells (DC’s) and the realization that small intestinal derived migratory DCs have an enhanced capacity to drive the generation of ‘gut tropic’ T cells compared with DC subsets from other tissues. More recently his laboratory has focused on the role intestinal DC subsets play in mucosal adaptive immune homeostasis. His laboratory demonstrated a key role for IRF4 dependent intestinal DCs in intestinal Th17 homeostasis and IRF8 dependent intestinal DCs in intestinal intraepithelial lymphocyte and Th1 cell homeostasis. His work has resulted in several awards including the Anders Jahre Young Researcher Award in Biomedicine from the University of Oslo and the Göran Gustafsson Prize in Medicine from the Swedish Royal Academy of Sciences. William Agace is one of three editors of ‘Mucosal Immunology’ and one of two European councilors on the board of the Society of Mucosal Immunology.

Pamela Schnupf
Institut Imagine/Institut Necker, Paris, France

Title: The Unique Interaction of the Potent Immunomodulatory Commensal SFB With its Host

Pamela Schnupf obtained her B.Sc. Honors degree in Biology from the University of Victoria in Canada and her Ph.D. in Microbiology from the University of California at Berkeley for her work with Dan Portnoy on the human pathogen Listeria monocytogenes. She then joined the laboratory of Philippe Sansonetti at the Institut Pasteur in Paris for a postdoctoral fellowship on the human enteropathogen Shigella flexneri, before collaborating with Nadine Cerf-Bensussan at Institut Imagine in Paris, for her second postdoctoral fellowship on the immunostimulatory gut commensal segmented filamentous bacteria (SFB). Since 2016, Pamela has been an INSERM Assistant Professor in the Intestinal Immunity laboratory of Nadine Cerf-Bensussan and is currently transitioning to group leader of the Host-Microbiota Interactions lab at Institut Necker in Paris. Pamela’s research focuses on the cross-talk between the microbiota and the host and the unique role of the microbiota, and notably the unusual SFB-host interaction, in stimulating an immunological milieu in the host that indirectly promotes pathogen resistance. One translational aim is to develop a novel vaccine delivery platform against diarrheal pathogens, for which Pamela has received a Bill and Melinda Gates Grand Challenge Grant.

LYMPHOCYTE ACTIVATION SESSION

David M. Samson
UCL Institute of Immunity and Transplantation, London

Title: Control of T Cell Responses by CTLA-4

David Sansom is Professor of Transplant Immunology at the UCL Institute for Immunity and Transplantation in London, based at the Royal Free Hospital. He did his BSc and PhD in Bristol, UK where he became interested in the susceptibility to autoimmunity, particularly rheumatoid arthritis. He held Senior Research Fellowships from Arthritis Research UK at the University of Bath, and the University of Birmingham before moving to University College London in 2013. In 2017 David became a Wellcome Trust Investigator. David’s lab works on various aspects of human immune regulation especially in the area of T cell biology, with a particular focus on understanding the molecular basis of CTLA-4 function. In 2011 he described a novel mechanism of CTLA-4 function termed “transendocytosis” providing a new perspective on CTLA-4 function. Since moving to the Royal Free Hospital he has been involved in the study of patients with heterozygous CTLA-4 defects who develop a variety of autoimmune conditions due to impaired regulatory T cell function. David is also interested in understanding autoimmune diseases by connecting immune phenotypes with human genetic variation.

Warren J. Leonard
National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA

Title: The YC Family of Cytokines and the Fine-tuning of Cytokine Signals

Dr. Leonard received his A.B. in mathematics, magna cum laude and Phi Beta Kappa, from Princeton University and his M.D. from Stanford University. After completing residency training in medicine at Barnes Hospital and a year of research in biochemistry at Washington University in St. Louis, Dr. Leonard came to the NIH as a postdoctoral fellow in the National Cancer Institute. He began his own laboratory in the National Institute of Child Health and Human Development and then joined the National Heart, Lung, and Blood Institute. Dr. Leonard has authored or co-authored more than 350 articles and book chapters and holds 20 patents. He is an Associate Editor and former Co-Editor of Immunity, on the editorial board of Cytokine, and a contributing member of the Faculty of 1000. He is past-President of the International Cytokine Society, a member of the Board and former Vice President of the Foundation for Advanced Education in the Sciences (FAES), and serves on the Council of the Association of American Physicians. Dr. Leonard is the recipient of many honors and awards, including the American Federation for Clinical Research Foundation Outstanding Investigator Award, the Food and Drug Administration Center for Biologics Evaluation and Research Outstanding Service Award, the American Association of Immunologists (AAI)-Huang Foundation Meritorious Career Award, and the Honorary Lifetime Membership Award of the International Cytokine and Interferon Society. He is an elected member of the American Society for Clinical Investigation, the Association of American Physicians, a Fellow of the American Association for the Advancement of Science, and a member of the National Academy of Medicine (formerly the Institute of Medicine), the National Academy of Sciences, and the American Academy of Arts and Sciences.

REGISTRATION

REGISTRATION FEES

EARLY BIRD

(Deadline: 15th May)

LATE REGISTRATION

(Late registration: 20th June)

ON-SITE

SPI member2 Non-member SPI member2 Non-member
Student1 55 75 70 95 150
Non-student 100 180 125 225 250

PAYMENT

Registration and membership fees payment by bank transfer to the SPI account. Payment instructions will be sent after registration.

Send proof of payment to spi.events@spimunologia.org

CONTACTS

Local Organizer

Natacha Gonçalves Sousa

Av. Professor Egas Moniz, Lisbon, Portugal – 38°44’47″N 9°9’40″W – View in Google Maps

Instituto de Medicina Molecular

IMM – Instituto de Medicina Molecular João Lobo Antunes Faculdade de Medicina da Universidade de Lisboa – Av. Professor Egas Moniz – Lisbon – Portugal View in Google Maps

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