This year’s edition of the annual meeting Sociedade Portuguesa de Imunologia (SPI) will be at IMM (Instituto de Medicina Molecular João Lobo Antunes), in Lisbon, from the 27th to 29th of June, 2018.
This meeting will focus on Metabolism, Cancer, Vaccines, Infection, Mucosal Immunology, Immune Regulation and Lymphocyte activation. We are privileged to host a fantastic panel of speakers (see details below).
We welcome your participation.
See you there,
The organizing committee,
Ana Espada Sousa
Natacha Gonçalves Sousa
Metabolism & Cancer Session
Ana I. Domingos University of Oxford, UK, Howard Hughes Medical Institute IRS, Maryland, US, Gulbenkian Science Institute, Portugal
Title: Sympathetic Neuroimmunity in Obesity
The laboratory of Dr Domingos focuses on neuroimmune mechanisms underlying obesity. Using optogenetics and multiphoton microscopy, among other tools, the laboratory of Dr Domingos has recently discovered a direct connection between adipocytes and the sympathetic nervous system (SNS). Moreover, they showed that this SNS neuro-adipose junction mediates fat mass reduction. Thus, direct and targeted pharmacologic activation of sympathetic inputs to adipose tissues could represent a novel strategy for the induction of fat loss and a new anti-obesity therapy that would circumvent the challenges of drug delivery to the brain. Howard Hughes Medical Institute, the Welcome Trust, the Human Frontiers Science Program, the European Molecular Biology Organization, and the Gulbenkian Foundation fund the laboratory of Dr Domingos. She has undergraduate training in mathematics, doctoral training in neurobiology mentored by Prof. Dr Leslie Vosshall and postdoctoral training in metabolism mentored by Prof. Dr Jeffrey Friedman, both at the Rockefeller University.
Lucie Peduto Institut Pasteur, France
Title: The Stromal Niche in Tissue Repair, Inflammation and Cancer
Lucie Peduto obtained her PhD from the University of Lausanne (Switzerland) in tumor biology. She did a postdoctoral fellowship at the Sloan-Kettering Institute, in New York, on the role of ADAMs proteases in the tumor microenvironment. She is now Associate Professor in the Department of Immunology, at the Institut Pasteur (France), directing a laboratory focusing on the role of stromal cells in inflammation and cancer. Her lab is more specifically interested in the stromal crosstalk with immune cells, endothelial cells and tissue stem cells, and exploring how perturbation of this fundamental crosstalk impact on disease pathogenesis. Lucie Peduto was awarded an ERC Consolidator Grant to pursue her research on the role of the stromal microenvironment in inflammatory/fibrotic diseases and cancer, aiming at identifying new (co)-therapeutic strategies.
Burkhard Becher University of Zurich, Switzerland
Title: The T Cell-Myeloid Connection in Tissue-Inflammation
Burkhard Becher studied Biology at the University of Cologne in Germany and specialized in Molecular Genetics and Biochemistry. In 1995, for his graduate studies he went to the Montreal Neurological Inst. at McGill University in Canada to train in Neuroimmunology with Jack Antel. His work focused on the role of microglia cells as brain-resident myeloid cells capable of instructing self-reactive T cells in the context of autoimmune neuro-inflammation. In 1999 he joined the lab of Randy Noelle at the Dartmouth Medical School to extend his work to in vivo models and transgenic mice. He developed tools to specifically manipulate microglial cells in vivo during inflammation. Burkhard’s focus is the function of cytokines and how these molecules permit cell-cell communication between immune cells. In 2003, he was recruited as Assistant Professor to the Neurology Department at the University Hospital of Zurich. There he continued to define the cytokine networks in inflammation. In 2008, he became full professor and chairman at the Institute of Experimental Immunology at the University of Zurich and heads the Unit for Inflammation Research.
VACCINES & INFECTION SESSION
Andre Ballesteros-Tato Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Alabama, USA.
Title: Regulation of the Germinal Center response to Influenza virus by IL-2
Andre completed his Ph.D. in Molecular Biology at the Autonoma University of Madrid in Spain in July 2007. In his Ph.D. thesis work, he studied the role of the cell cycle inhibitor p21 and the apoptosis-inducing Fas receptor in controlling immunological tolerance in different murine and human autoimmune diseases. Beginning in March of 2008, Andre joined the laboratory of Dr. Troy Randall at Trudeau Institute as a postdoctoral fellow, and then later moved with Dr. Randall’s lab to the University of Rochester. As a postdoc, he studied how dendritic cell (DC) subsets responded to influenza infection and how they controlled CD8+ T cell priming and promoted memory T cell differentiation. These previous studies have stimulated his interest in how cells of the innate immune system, particularly DCs, monocytes and their progeny, control both early inflammation and ultimately T and B cell responses to pathogens. After joining the University of Alabama as an assistant professor in June 2015, Andre’s laboratory is studying the cellular interactions, the environmental cues and the molecular mechanisms that control the differential capacity of distinct populations of DCs to regulate T and B cells responses in different models of infection and autoimmune diseases.
Matteo Iannacone San Raffaele Scientific Institute, Milan, Italy
Title: Spatiotemporal dynamics of naive CD8+ T cells undergoing intrahepatic priming
Matteo Iannacone obtained a M.D. degree from the University of Milan, Italy, followed by a residency in Internal Medicine and a Ph.D. in Immunology from Vita-Salute San Raffaele University in Milan, Italy. He trained as a postdoctoral fellow at The Scripps Research Institute, La Jolla, CA and at Harvard Medical School, Boston, MA. Since 2010, he directs the Dynamics of Immune Responses Laboratory at the San Raffaele Scientific Institute in Milan, Italy. By combining cutting-edge in vivo imaging techniques and advanced animal models, Matteo has made fundamental contributions to our understanding of the immune response and viral-induced immunopathology. His work has been published in the most important scientific journals (including Nature, Science, Cell, Immunity, Nature Medicine) and he holds 6 international patents. He has received numerous awards for his work, including the Armenise-Harvard Foundation Career Development Award, an ERC Starting Grant, the Young Investigator Award from the European Association for the Study of the Liver, the EMBO Young Investigator Award, the Chiara D’Onofrio Award and an ERC Consolidator Grant.
MUCOSAL IMMUNOLOGY & IMMUNE REGULATION SESSION
Denise Morais da Fonseca University of São Paulo, Brazil
Title: Immunological scarring. Understanding chronic effects of acute infections
Denise Morais da Fonseca is an Assistant Professor at the Institute of Biomedical Sciences – University of São Paulo – Brazil. She obtained her Ph.D. in 2010 from the University of São Paulo on the regulation of the immune response during airway inflammation. Following a postdoctoral period at the University of São Paulo, working on immune regulation during intestinal parasitic infections, she joined the Laboratory of Parasitic Diseases – National Institutes of Allergy and Infectious Diseases, USA in 2012 as post-doctoral fellow. Since then, her work over the past years aims at understanding how acute infections at mucosal barriers, such as the gut and lungs, have long-term impact on tissue function and homeostasis. Barrier tissues are sites of constitutive colonization by commensals and exposition to environmental antigens. Therefore, the mucosal-associated immune system is endowed with specialized mechanisms of immunity and regulation, allowing for the tolerance of constant exposure to innocuous antigens while maintaining the capacity to rapidly respond to encounters with pathogens. Failure to restore initial homeostasis post-infection and the long-term consequences of encounters with pathogens have been the focus of our current studies. The scientific goal of the Laboratory of Mucosal Immunology is to understand the mechanisms underlying the development of systemic immune and metabolic pathologies following acute infections. More particularly, their research plan aims to 1) identify the mechanisms sustaining the infection-induced scarring/remodeling of the immune system, 2) define how infection-induced remodeling of the mesentery drives the development of host metabolic dysfunction, and 3) describe the main pathways mediating the regulation of immune homeostasis in the adipose tissue and susceptibility to metabolic disease.
Pamela Schnupf Institut Pasteur, France
LYMPHOCYTE ACTIVATION SESSION
David M. Samson University College London, UK
(Deadline: 15th May)
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Instituto de Medicina Molecular
IMM – Instituto de Medicina Molecular João Lobo Antunes Faculdade de Medicina da Universidade de Lisboa – Av. Professor Egas Moniz – Lisbon – Portugal View in Google Maps